Glycan Analysis Kits
The mAbsolute kits, are low- and high-throughput glycan analysis kits, based on highly pure synthetic isotope-labeled internal standards for the absolute quantification of mAb glycosylation by MALDI-TOF MS. Minimal handling and time are required for sample preparation and within seconds, all relevant glycans of a deglycosylated mAb sample are quantified by comparison of MALDI profiles with the corresponding internal reference standards.
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The mAbsolute Complete kit also contains isotope-labeled standards for the three most frequently found α-2,3-sialylated glycans. Although they naturally occur in low amounts at the Fc part of an antibody, they can strongly influence effector function.
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The mAbsolute Neutral kit library of bi-antennary, heavy isotope-labeled N-glycan standards has been designed for the typical, CHO cell-produced, Fc N-glycosylation profile of monoclonal antibodies.
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The mAbsolute Human Serum IgG kit contains pauci-mannose, truncated, biantennary and bisected isotope-labeled standards including α-2,6-sialylation. The mixture of standards has been designed for the typical Fc and Fab N-glycosylation profile of IgG 1 type antibodies from human serum.