Rheumatoid arthritis, Systemic lupus erythrematosus, Sjogren’s syndrome, Juvenile-onset chronic arthritis, Crohn´s syndrome, Tuberculosis

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Rheumatoid arthritis, Systemic lupus erythrematosus, Sjogren’s syndrome, Juvenile-onset chronic arthritis, Crohn´s syndrome, Tuberculosis

Rheumatoid arthritis, Systemic lupus erythrematosus, Sjogren’s syndrome, Juvenile-onset chronic arthritis, Crohn´s syndrome, Tuberculosis Biomarkers

Increasing levels

  • Elevated proportion of IgG G0 glycoforms.

Rheumatoid arthritis, Systemic lupus erythrematosus, Sjogren’s syndrome, Juvenile-onset chronic arthritis, Crohn´s syndrome, Tuberculosis Biomarkers

Increasing levels

  • Reduced degree of antennae sialylation and galactosylation for IgG N glycans.

References:
[29] Ercan et al. Hypogalactosylation of serum N-glycans fails to predict clinical response to m and TNF inhibition in rheumatoid arthritis.Arthritis Research & Therapy 2012, 14:R43.

[30] James N. Arnold et al., Mannan binding lectin and its interaction with immunoglobulins inhealth and in disease, Immunology Letters 106 (2006) 103–110.

[31] Pauline M. Rudd et al. Glycosylation and the Immune System. Science 291, 2370 (2001).

[32] Arnold, J. N:, et al., The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu. Rev. Immunol. 25, 21-50 (2007).