Congenital Disorders of Glycosylation

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Congenital Disorders of Glycosylation

Congenital Disorders of Glycosylation Biomarkers

Increasing levels

  • Glycan analysis of serum proteins, such as the Igs that collectively account for up to 50% of the serum glycoproteins, provides diagnostic information that can pinpoint the faulty step in the pathway.
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

Congenital Disorders of Glycosylation Biomarkers

Decreasing levels

  • Decreased leveles of sialylated glycans.
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

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