Gastric cancer

breathcrumb

Gastric cancer

Gastric Cancer Biomarkers

Increasing levels

  • Increased levels of triantennary glycans carrying 2,6-linked sialic acids, and trisialylated triantennary glycans carrying sialyl Lewis X.
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

Gastric Cancer Biomarkers

Decreasing levels

  • Decreased levels of fucosylated non- and mono-sialylated glycans. 
  • Decreased levels of biantennary asialo monogalactosylated glycans, and triantennary glycans carrying 2,3-linked sialic acids.
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

References:
[7] J. Bones, et al., Ultra performance liquid chromatographic profiling of serum N-glycans for fast and efficient identification of cancer associated alterations in glycosylation, Anal. Chem. 82 (2010) 10208–10215.

[8] J. Bones, et al., Glycomic and glycoproteomic analysis of serum from patients with stomach cancer reveals potential markers arising from host defence response mechanisms, J. Proteome Res. 10 (2011) 1246–1265.