Hepatocellular carcinoma

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Hepatocellular carcinoma

Hepatocellular Carcinoma Biomarkers

Increasing levels

  • Increased levels of the fucosylated triantennary glycan.
  • Highly increased fucosylation.
  • Increased sialylation and high mannose structures
  • Increased fucosylation and syalylation of haptoglobin
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

Hepatocellular Carcinoma Biomarkers

Decreasing levels

  • Decreased levels of a tri- and a tetraantennary glycan.
  • Decrease of G2F levels correlates with halting of Hepatoma Cell Migration and Invasion.
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

References:
[9] Goldman, R., et al., (2009) Detection of hepatocellular carcinoma using glycomic analysis. Clin. Cancer Res. 15, 1808–1813.

[10] Liu, X. E., et al., (2007) N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus. Hepatology 46, 1426–1435.

[11] K. Noda, et al, Gene expressionof α1-6 fucosyltransferase in human hepatoma tissues: a possible implicationfor increased fucosylation of α-fetoprotein, Hepatology 28 (1998), 944–952.

[12] Y. Sato, et al.,Early recognition of hepatocellular carcinoma based on altered profiles of alphafetoprotein,N. Engl. J. Med. 328 (1993) 1802–1806.

[37] Kizuka Y. “An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA”. Cell Chem Biol. 2017.

[39] Menezes de Oliveira et al. “Use of Mass Spectrometry to Screen Glycan Early Markers in Hepatocellular Carcinoma“. Front. Oncol. 2018.