IgA Nephropathy

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IgA Nephropathy

IgA Nephropathy Biomarkers

Increasing levels

  • IgG and IgM variable region glycans containing one or more oligomannose sugars. Significant increase in potential glycosylation sites in the variable region.Agalactosyl biantennary glycans G0F and glycans containing sLex epitope A3F1G1 and A2F1G1.
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

IgA Nephropathy Biomarkers

Decreasing levels

  • Aberrant O-glycosylation of serum IgA1 in patients is ascribed to a decrease in terminal galactosylation and sialylation.
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

References:
[32] Arnold, J. N:, et al., The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu. Rev. Immunol. 25, 21-50 (2007).