Maturity-onset diabetes of the young (MODY)

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Maturity-onset diabetes of the young (MODY)

Maturity-onset diabetes of the young (MODY) Biomarkers

Increasing levels

  • Agalactosyl biantennary glycans G0F and glycans containing sLex epitope A3F1G1 and A2F1G1.Lewis a in tri- biantennary N-glycans in serum and plasma.
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

Maturity-onset diabetes of the young (MODY) Biomarkers

Decreasing levels

  • Lewis a in tri- biantennary N-glycans in serum and plasma.
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

References:
[33] Gaya Thanabalasingham, G. Lauc, et al., “Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile“, Diabetes 2013, 62, 1329.