Pancreatic cancer

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Pancreatic cancer

Pancreatic cancer Cancer Biomarkers

Increasing levels

  • Increase of core fucosylation and Lex in tri-antennary glycans.
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

References:
[23] N. Okuyama, et al., Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation, Int. J. Cancer 118 (2006) 2803–2808.

[24] E. Miyoshi, M. Nakano, Fucosylated haptoglobin is a novel marker for pancreatic cancer: detailed analyses of oligosaccharide structures, Proteomics 8 (2008) 3257–3262.

[25] Nakano M, et al., Site specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: a novel approach for the development of tumor markers. Int J Cancer 2008;122: 2301–9.