Pancreatic cancer

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Pancreatic cancer

Pancreatic cancer Cancer Biomarkers

Increasing levels


  • Increase of core fucosylation and Lex in tri-antennary glycans
  • Glycan Standard 13C Biantennary A1(3) (Sial α-2,3)
  • Glycan Standard 13C Tetraantennary A4-G1a
  • Bis α-2,6-sialylated biantennary glycopeptide from egg yolk
  • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

Prostate Cancer Biomarkers

Decreasing levels


    • Bis α-2,3-sialylated, galactosylated biantennary glycopeptide

    References:
    [1] R. Saldova, et al., Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor cell counts, Ann. Oncol. 22 (2011) 1113–1119.

    [2] U.M. Abd Hamid, et al., A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression, Glycobiology 18 (2008) 1105

    [3] Z. Kyselova, et al., Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles, Clin. Chem. 54 (2008) 1166–1175.

    [4] A. Pierce, et al., Levels of specific glycans significantly distinguish lymph node–

    [5] de Leoz, M. L., et al., (2011) High-mannose glycans are elevated during breast cancer progression. Mol. Cell. Proteomics 10, M110.00271

    [6] Alley, W. R., Jr., et al., (2010) Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancerbiomarker discovery. Anal. Chem. 82, 5095–5106